Literature summary extracted from

Schaer, C.A.; Owczarek, C.; Deuel, J.W.; Schauer, S.; Baek, J.H.; Yalamanoglu, A.; Hardy, M.P.; Scotney, P.D.; Schmidt, P.M.; Pelzing, M.; Soupourmas, P.; Buehler, P.W.; Schaer, D.J.
Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics (2018), BMC Biotechnol., 18, 15 .

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.41	endoplasmic reticulum	-	Homo sapiens	5783	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.41	prohaptoglobin + H2O	Homo sapiens	the enzyme cleaves prohaptoglobin after arginine R102 in variants Hp1F and Hp1S or after R161 in variant Hp2FS	haptoglobin + ?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.41	Homo sapiens	Q9NZP8	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.41	FS-293F cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.41	prohaptoglobin + H2O	the enzyme cleaves prohaptoglobin after arginine R102 in variants Hp1F and Hp1S or after R161 in variant Hp2FS	Homo sapiens	haptoglobin + ?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.4.21.41	?	x * 68000, SDS-PAGE	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.41	C1r-LP	-	Homo sapiens
3.4.21.41	complement C1r subcomponent-like protein	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)